HISTORICAL PERSPECTIVE
An English physiologist by the name of Thomas Willis is credited with clinically describing myasthenia gravis in 1672. Doctors Samuel Goldflam, Wilhelm Erb, and Friedrich Jolly from Germany are responsible for fully describing myasthenia gravis in 1890. In 1934, Dr. Mary Walker of London conducted a successful trial of physostigmine in a patient with myasthenia gravis. Dr. Walker discovered that a subcutaneous injection of physostigmine temporarily restored muscle function in a patient with myasthenia gravis. At that time, physostigmine was used as an antidote for curare poisoning.
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